School of Inorganic Nanocarriers for Delivery of Therapeutic Agents:

Diagnosis and Treatment

So far, huge investments, such as financial resources, materials, and even manpower, have been made to advance new therapeutic approaches for cancer. However, current clinical therapeutic choices have limited success due to tumor heterogeneity, complexity, and diversity.

Although researchers have focused on developing alternate potent, safe, and cost-effective treatments to refine the conventional cancer treatment techniques. Aversive side effects of conventional cancer therapies showed that these methods are not effective enough. Therefore, material scientists, chemists, biologists, pharmacologists, and clinicians joined to discover innovative technologies for finding effective, efficient, affordable, and acceptable cancer therapeutic options.

In the biomedical field, several nanotechnology-based approaches have influenced the development of therapeutic drugs and pharmaceutical formulations. In particular, the increasing burden to human health caused by serious diseases (e.g., various types of cancers, coronary artery disease (CAD), etc.) has required ongoing innovations in drug delivery and drug-eluting systems, many of which rely on nanotechnology.

The main applications of these new drug-delivery and targeting systems have been focused on imaging agents for cancer diagnosis and the development of new anticancer drugs and strategies. Nanocarrier-based delivery systems can be used to increase the safety and efficacy of active ingredients in medical, particularly when such ingredients are unstable, sparingly soluble, or cause off-target effects. Biocompatible inorganic material-based nanosystems provide a novel choice to effectively circumvent the intrinsic drawbacks of traditional organic materials in biomedical applications, especially in overcoming the multidrug resistance (MDR) of cancer cells due to their unique structural and compositional characteristics, for example, high stability, large surface area, tunable compositions, abundant physicochemical multi functionalities, and specific biological behaviors. In view of this, the main goal of this winter school is to examine inorganic nanoparticle-based carrier systems (gold nanoparticles, quantum dots, upconversion nanoparticles, etc.) for the delivery of therapeutic agents such as drugs, genes, and various biomolecules, with an emphasis on the structural and biological aspects.

School Supervisor

Prof. Zahra Shariatinia

Faculty of Chemistry

Department of Applied and Organic Chemistry (See more)

Goals:

  • Structural study of drug nanocarriers based on inorganic nanoparticles
  • A biological study of drug nanocarriers based on inorganic nanoparticles
  • Structural study of gene or biomolecule nanocarriers based on inorganic nanoparticles
  • A biological study of gene or biomolecule nanocarriers based on inorganic nanoparticles